Professor - Emeritus
B.A., Physics and Chemistry University of Toronto, 1952;
M.Sc., Physical Chemistry McMaster University, 1955;
Ph.D., Biophysics The University of Chicago, 1957
We study the mechanism of molecular motors, myosin with actin and kinesin with microtubules. The objective is to show how the steps in the kinetic mechanism determine the structural changes which produce force and motion.
To disect the steps in the system mutant kinesins, expressed in bacteria, are studied in which a step in the mechanism is blocked. The results are correlated with the structure of the protein and its motility properties determined by in vitro assay.