SUNY at Stony Brook, B.S. Biology, 1975;
University of Florida, M.S. Zoology, 1977;
Harvard University, Ph.D. Population Genetics, 1983
My research centers on molecular population genetics and evolution. I am interested in understanding the evolutionary basis for high levels of polymorphisms within species, and in determining whether natural selection contributes to the maintenance of within- species variation. I am also interested in knowing whether molecular evolution between species results from the same evolutionary forces that produce intra-species variation. Using the alcohol dehydrogenase locus (Adh) as a model system, our studies reveal how selection has contributed to the evolution of the locus over three time scales: affecting populations, affecting species, and affecting long-term molecular evolution. Finally, because our ability to acquire molecular data is limited by technology, I place a special emphasis on developing better methods for measuring genetic variation. Current projects in the lab include the role of natural selection in the evolution of codon nias, the relationship between recombination rates and levels on nucleotide polymorphism, and the forces of governing variation in the mitrochondrial genome of fruitflies.