B.S., Zoology, Duke University, 1980
Ph.D., Zoology, University of Washington, 1986
Our interests center on the molecular mechanisms by which signal transduction pathways, particularly those involved in growth control and regulation of the apical cytoskeleton, are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such membrane-associated complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes via mutagenesis, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.