B.S., Biology & Chemistry, Bates College, 1990
Ph.D., Biochemistry & Biophysics, UCSF, 1998
Postdoctoral, Biochemistry & Biophysics, UCSF, 1999
Our research interfaces biology and chemistry to understand the molecular mechanisms that underlie fundamental biological processes. Current research topics include:
1. Membrane protein biogenesis. How are newly synthesized membrane proteins targeted to the correct intracellular membrane? Once there, how are they inserted into the bilayer? A major focus in the lab is the study of co- and post-translational targeting and insertion pathways. Our long-term goal is to decipher common structural and mechanistic themes in membrane protein biogenesis.
2. Membrane protein quality control. What happens to membrane proteins that fail to engage the targeting and insertion machinery? What happens if they are inserted into the wrong membrane? Or when a properly inserted membrane protein becomes damaged? To help protect against damage caused by such events, cells have evolved complex pathways that identify and destroy misfolded and/or mislocalized membrane proteins.